Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia

M S Buchanan; A Edser; G King; J Whitmore; R J Quinn

doi:10.1021/np0004597

Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia

J Nat Prod. 2001 Mar;64(3):300-3. doi: 10.1021/np0004597.

Authors

M S Buchanan¹, A Edser, G King, J Whitmore, R J Quinn

Affiliation

¹ AstraZeneca R & D Griffith University, Brisbane, Queensland, Australia, 4111.

PMID: 11277743
DOI: 10.1021/np0004597

Abstract

Four cheilanthane sesterterpenoids, 25-hydroxy-13(24),15,17-cheilanthatrien-19,25-olide (1), 13,16-epoxy-25-hydroxy-17-cheilanthen-19,25-olide (2), 25-hydroxy-13(24),17-cheilanthadien-16,19-olide (3), and 16,25-dihydroxy-13(24),17-cheilanthadien-19,25-olide (4), were isolated from the marine sponge Irciniasp. Compounds 1, 3, and 4 are new natural products. The four compounds inhibit MSK1 (mitogen and stress activated kinase) and MAPKAPK-2 (mitogen activated protein kinase activated protein kinase), two protein kinases involved in mitogen and stress signal transduction.

MeSH terms

Animals
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Magnetic Resonance Spectroscopy
Molecular Structure
Porifera / chemistry*
Protein Kinase Inhibitors*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*

Substances

Enzyme Inhibitors
Protein Kinase Inhibitors
Sesquiterpenes